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BIOCOR
SCIENTIFIC
Clinical Studies
BioCor Scientific is a company that offers a
wide variety of biomedical consulting
services including the evaluation of
products through a variety of test models.
We have reviewed test reports from other
laboratories and conducted our own tests on
the skin lotion marketed as Gloves In A
Bottle.
In testing it is difficult to represent the
broad range of chemical irritants and toxins
which human skin may encounter in this day
and age. By using hydrochloric acid,
ammonia, and isocyanate as testing agents,
however, we have attempted to cover
extremely diverse chemical species which
will likely be encountered in the household
and work place. Both hydrochloric acid and
liquid ammonia comprise ions and small
inorganic molecules and are excellent
solvents and would be expected to penetrate
the skin on this basis alone. Isocyanates
are slightly larger molecules which, when
linked to carbon-containing groups in
products such as paint hardener, form
polyisocyanates. Polyisocyanates are
insoluble in water and are irritating to
skin and other tissues by contact or by
inhalation of vapors.
A commercial form of liquid ammonia was used
in our experimental trials at 4%
concentration. The solution consists primary
of large quantities of water and ammonia and
smaller quantities of ammonium ion and
hydroxide ion. This level of concentration
is irritating to the skin. Hydrochloric acid
is a very strong electrolyte, whose
hydronium and chloride ions are largely
dissociated, making each extremely reactive.
All three testing agents are found in
household and work place products and, as
indicated above, have the potential to
penetrate human skin by diverse and
insidious means. Our intent has been to test
the efficacy of barrier cream/lotion
protection against the more extreme examples
of chemical penetration. At BioCor
Scientific we have evaluated the protective
value of Gloves In A Bottle against liquid
ammonia, isocyanate in xylene, and the
polyisocyanate product DCX61 in testing
models chosen to simulate the skin of the
human hand. Despite dosages of chemical
irritant in excess of those likely to be
experienced in the household or work place,
Gloves In A Bottle demonstrated protection
against skin and systemic reactions in all
cases. Because of our choice of skin
irritating test agents, including their
organic solvents, and the level of
protection demonstrated, it is likely that
Gloves In A Bottle would help protect
against most chemical irritants, solvents,
and toxin encountered in the household and
work place.
Sincerely,
Vernon Roohk, Ph.D.
January 25, 1998
Please note: Gloves In
A Bottle, Inc. makes no claims its product
is effective in protecting against any
chemicals or irritants other than dirt and
grime. The results of independent laboratory
testing are being posted only to show that
testing has been conducted, to show it is
effective against dirt and grime and no
other inference should be construed from the
above report.
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Bio Screen Testing Services, Inc. performed repeat insult patch tests on 50 subjects following a full disclosure and their informed consent. This is the accepted method of testing topically applied products for the possibilities for skin irritation or sensitivity.
The test is conducted by placing an ample amount of Gloves In A Bottle on an airtight patch and then applying that patch for 5 exposures to the same area of skin. Each exposure is for 48 hours. Each exposure is followed by a resting period 48 hours. This is followed by a 7 - 14 day resting period. Then the above test is repeated on an adjacent area of skin. Gloves In A Bottle did not produce any reaction or sensitivity during the entire testing period on any of the 50 women tested. These clinical trials gives Gloves In A Bottle the highest hypoallergenic and "safe use" rating.
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BioScreenŽ Testing Services, Inc.
Analytical Report
Gloves In A Bottle, Inc.
P.O. Box 615
Montrose, CA 91021
Report Date: 12/01/98
Date Received: 10/20/98
Date Completed: 12/01/98
Project #: 38821
SAMPLE DESCRIPTION:
ACCESSION #: 38821
SAMPLE: White Lotion
TEST PERFORMED:
Human Patch Test (50 Subject)
RESULTS:
Human Patch Test
ACC # 38821
No evidence of sensitization
* See attached report
(For a copy of the full clinical study email klaus@glovesinabottle.com)
Ranil M. Fernando, B.S.
Operation Manager
* Test conducted at an outside laboratory.
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| Warning:
Always follow manufacturer's safety directions
when handling any harmful substance. Gloves In A
Bottle is not a substitute for required safety
protection, including gloves. |
*
Gloves In A Bottle, Inc. makes no claims that its
product could be used in the diagnosis, cure,
mitigation, treatment, or prevention of eczema,
psoriasis, skin allergies, dermatitis, or any
other disease; or is intended to affect the
structure or any function of the body.
Gloves In A Bottle is not intended to protect
against any chemicals or irritants other than dirt
and grime. Always follow manufacturer's safety
directions when handling any harmful substance.
Gloves In A Bottle is not a substitute for
required safety protection, including gloves. |
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